By engaging ICP Firefly early during the development of your drug candidate you can avoid late development failure and conserve your resources for future development.
We can provide pilot data for the design of definitive toxicology studies
We can develop or transfer validated bioanalytical methods to accommodate your unique needs. Specialty LC-MS solutions include: Peptides and Proteins, Oligonucleotides, herbal compounds.
Toxicokinetic studies (TK): Blood level monitoring to correlate safety in animal models; formulation analysis.
Pharmacokinetic (PK) including screening studies: Monitor lead compound pharmacokinetics and predict metabolism/PK in humans.
Clinical studies, PK, bioavailability studies: Determine the clinical bioavailability during drug development, measure rates of distribution and elimination, drug concentration for therapeutic site.
Bioequivalence studies: Compare generics to establish extends and rates of absorption.
ICP Firefly can provide high sensitivity and specificity using liquid chromatography-mass spectrometry (LC-MS/MS) bioanalytical services. LC-MS/MS is a powerful tool for drug development for both pharmacokinetic analysis and identification of key metabolites and impurities.
ICP Firefly will help you to characterise your drug candidate's absorption, distribution, metabolism and excretion (ADME) properties to support successful candidate selection.
We offer world class expertise and resources to conduct metabolites identification and profiling using accurate max measurements for state-of-the-art structural characterisation. All our projects are initiated within 5 days of award.